作者: /

徐媛曼 教授

Hsu, Yuan-Man

Email：yuanmh@thu.edu.tw

徐媛曼(第八及碩士班家族)Hsu, Yuan-Man
職稱
Title		特聘教授
Distinguished Professor
學生訪談時間
Students time		星期三 9:00~12:00
Wed. 9:00~12:00
聯絡方式
Contact		Tel: 886-04-23590121轉37114
Fax: 886-04-23590385 
E-mail: yuanmh@thu.edu.tw
學經歷
Background		學歷
美國康乃爾大學獸醫學院群體醫學及診斷學研究所博士
Ph.D. in Department of Population Medicine and Diagnostic Sciences, College of Veterinary Medicine, Cornell University, Ithaca, New York, USA
國立台灣大學獸醫學系學士
Bachelor in Department of Veterinary Medicine, National Taiwan University, Taipei, Taiwan
現職及專長相關之經歷
2021/08 – 迄今      東海大學畜產與生物科技學系 教授
2021/08 – 迄今      中國醫藥大學生物科技學系 兼任教授
10/2012 – 2021/07  中國醫藥大學生物科技學系 教授
02/2020 – 2021/07  中國醫藥大學生命科學院代理院長
08/2015 – 08/2016   中國醫藥大學研究發展處 研發長
09/2014 – 07/2015   中國醫藥大學研究生事務處 處長
08/2013 – 07/2014   中國醫藥大學生物科技學系 系主任
08/2007 – 09/2012   中國醫藥大學生物科技學系 副教授
研究方向
Research		微生物學、分子生物學、細菌致病機轉、中草藥結合益生菌之動物保健產品開發
Microbiology, Molecular Biology, Bacterial Pathogenesis, Development of animal health supplements combined with herbal medicine and probiotics
授課名稱
Courses		大學部
微生物學(0-2)
Microbiology(0-2)
研究所 Graduate Program
消化道微生物特論(3-0)
Advanced Gastrointestinal microflora (3-0)
生物醫學研究方法(2-0)
Research Methodology of Molecular Medicine(2-0)
微生物遺傳學特論(3-0)
Advanced Microbial Genetics (3-0)
人畜共通傳染病(0-2)
Zoonoses(0-2)

細菌致病機轉、益生菌作用機制、中草藥結合益生菌之動物保健產品開發

Bacterial Pathogenesis, Probiotic Mechanisms of Action, and Development of animal health supplements combined with herbal medicine and probiotics

  1. Wang, W. L.; Hsu, Y. M.; Lin, M. L.; Chen, S. S.; Lai, Y. H.; Huang, C. H.*; Yao, C. H.*, Ex vivo model to evaluate the antibacterial and anti-inflammatory effects of gelatin–tricalcium phosphate composite incorporated with emodin and lumbrokinase for bone regeneration. Bioengineering 2023 Jul, 10(8):906-922. (SCI期刊)
  2. Do, A. D.; Su, C. H.; Hsu, Y. M.*, Antagonistic activities of Lactobacillus rhamnosus JB3 against Helicobacter pylori infection through lipid raft formation. Frontiers in immunology 2022 Jan, 14(12): 796177. (SCI期刊)
  3. Yang, J. S.; Kang, C. Y.; Su, C. H.; Chen, C. J.; Chiu, Y. J.*; Hsu, Y. M.*, Helicobacter pylori targets in AGS human gastric adenocarcinoma: in situ proteomic profiling and systematic analysis. Anticancer research 2022 Jan, 42(1): 531-546. (SCI期刊)
  4. Huynh, T. K.; Huang, C. H.; Chen, J. Y.; Yao, J. H.; Yang, Y. S.; Wei, Y. L.; Chen, H. F.; Chen, C. H.; Tu, C. Y.; Hsu, Y. M.; Liu, L. C.; Huang, W. C.*, MiR-221 confers lapatinib resistance by negatively regulating p27 kip1 in HER2-positive breast cancer. Cancer Science 2021 Oct, 112(10): 4234-4245. (SCI期刊)
  5. Tsai, S. C.; Lu, C. C.; Bau, D. T.; Chiu, Y. J.; Yen, Y. T.; Hsu, Y. M.; Fu, C. W.; Kuo, S. C.; Lo, Y. S.; Chiu, H. Y.; Juan, Y. N.; Tsai, F. J.; Yang, J. S., Approaches towards fighting the COVID-19 pandemic (Review). International Journal of Molecular Medicine 2021, 47 (1), 3-22. (SCI期刊)
  6. Do, A. D.; Chang, C. C.; Su, C. H.; Hsu, Y. M.*, Lactobacillus rhamnosus JB3 inhibits Helicobacter pylori infection through multiple molecular actions. Helicobacter 2021, 26 (3). (SCI期刊)
  7. Chang, P. Y.; Tsai, F. J.; Bau, D. T.; Hsu, Y. M.; Yang, J. S.; Tu, M. G.; Chiang, S. L., Potential effects of allyl isothiocyanate on inhibiting cellular proliferation and inducing apoptotic pathway in human cisplatin-resistant oral cancer cells. Journal of the Formosan Medical Association 2021, 120 (1), 515-523. (SCI期刊)
  8. Yang, J. S.; Chiang, J. H.; Tsai, S. C.; Hsu, Y. M.; Bau, D. T.; Lee, K. H.; Tsai, F. J., In Silico De Novo Curcuminoid Derivatives From the Compound Library of Natural Products Research Laboratories Inhibit COVID-19 3CL(pro) Activity. Natural Product Communications 2020, 15 (9). (SCI期刊)
  9. Tsai, C. B.; Hsia, N. Y.; Wang, Z. H.; Yang, J. S.; Hsu, Y. M.; Wang, Y. C.; Chang, W. S.; Bau, D. T.; Yin, M. C.; Tsai, C. W., The Contribution of MMP-9 Genotypes to Pterygium in Taiwan. Anticancer Research 2020, 40 (8), 4523-4527. (SCI期刊)
  10. Liu, S. P.; Shibu, M. A.; Tsai, F. J.; Hsu, Y. M.; Tsai, C. H.; Chung, J. G.; Yang, J. S.; Tang, C. H.; Wang, S. L.; Li, Q. W.; Huang, C. Y., Tetramethylpyrazine reverses high-glucose induced hypoxic effects by negatively regulating HIF-1 alpha induced BNIP3 expression to ameliorate H9c2 cardiomyoblast apoptosis. Nutrition & Metabolism 2020, 17 (1). (SCI期刊)
  11. Lin, C. C.; Huang, W. C.; Su, C. H.; Lin, W. D.; Wu, W. T.; Yu, B.; Hsu, Y. M.*, Effects of Multi-Strain Probiotics on Immune Responses and Metabolic Balance in Helicobacter pylori-Infected Mice. Nutrients 2020, 12 (8). (SCI期刊)
  12. Huang, T. Y.; Peng, S. F.; Huang, Y. P.; Tsai, C. H.; Tsai, F. J.; Huang, C. Y.; Tang, C. H.; Yang, J. S.; Hsu, Y. M.; Yin, M. C.; Huang, W. W.; Chung, J. G., Combinational treatment of all-trans retinoic acid (ATRA) and bisdemethoxycurcumin (BDMC)-induced apoptosis in liver cancer Hep3B cells. Journal of Food Biochemistry 2020, 44 (2). (SCI期刊)
  13. Chiang, J. H.; Tsai, F. J.; Hsu, Y. M.; Yin, M. C.; Chiu, H. Y.; Yang, J. S., Sensitivity of allyl isothiocyanate to induce apoptosis via ER stress and the mitochondrial pathway upon ROS production in colorectal adenocarcinoma cells. Oncology Reports 2020, 44 (4), 1415-1424. (SCI期刊)
  14. Wu, K. M.; Hsu, Y. M.; Ying, M. C.; Tsai, F. J.; Tsai, C. H.; Chung, J. G.; Yang, J. S.; Tang, C. H.; Cheng, L. Y.; Su, P. H.; Viswanadha, V. P.; Kuo, W. W.; Huang, C. Y., High-density lipoprotein ameliorates palmitic acid-induced lipotoxicity and oxidative dysfunction in H9c2 cardiomyoblast cells via ROS suppression. Nutrition & Metabolism 2019, 16. (SCI期刊)
  15. Lu, C. C.; Chiang, J. H.; Tsai, F. J.; Hsu, Y. M.; Juan, Y. N.; Yang, J. S.; Chiu, H. Y., Metformin triggers the intrinsic apoptotic response in human AGS gastric adenocarcinoma cells by activating AMPK and suppressing mTOR/AKT signaling. International Journal of Oncology 2019, 54 (4), 1271-1281. (SCI期刊)
  16. Liu, S. C.; Tsai, C. H.; Wu, T. Y.; Tsai, C. H.; Tsai, F. J.; Chung, J. G.; Huang, C. Y.; Yang, J. S.; Hsu, Y. M.; Yin, M. C.; Wu, Y. C.; Tang, C. H., Soya-cerebroside reduces IL-1 beta-induced MMP-1 production in chondrocytes and inhibits cartilage degradation: implications for the treatment of osteoarthritis. Food and Agricultural Immunology 2019, 30 (1), 620-632. (SCI期刊)
  17. Lin, K. H.; Li, C. Y.; Hsu, Y. M.; Tsai, C. H.; Tsai, F. J.; Tang, C. H.; Yang, J. S.; Wang, Z. H.; Yin, M. C., Oridonin, A natural diterpenoid, protected NGF-differentiated PC12 cells against MPP+ – and kainic acid-induced injury. Food and Chemical Toxicology 2019, 133. (SCI期刊)
  18. Lin, C. C.; Chen, K. B.; Tsai, C. H.; Tsai, F. J.; Huang, C. Y.; Tang, C. H.; Yang, J. S.; Hsu, Y. M.; Peng, S. F.; Chung, J. G., Casticin inhibits human prostate cancer DU 145 cell migration and invasion via Ras/Akt/NF-kappa B signaling pathways. Journal of Food Biochemistry 2019, 43 (7). (SCI期刊)
  19. Lee, H. P.; Wang, S. W.; Wu, Y. C.; Tsai, C. H.; Tsai, F. J.; Chung, J. G.; Huang, C. Y.; Yang, J. S.; Hsu, Y. M.; Yin, M. C.; Li, T. M.; Tang, C. H., Glucocerebroside reduces endothelial progenitor cell-induced angiogenesis. Food and Agricultural Immunology 2019, 30 (1), 1033-1045. (SCI期刊)
  20. Lee, H. P.; Chen, P. C.; Wang, S. W.; Fong, Y. C.; Tsai, C. H.; Tsai, F. J.; Chung, J. G.; Huang, C. Y.; Yang, J. S.; Hsu, Y. M.; Li, T. M.; Tang, C. H., Plumbagin suppresses endothelial progenitor cell-related angiogenesis in vitro and in vivo. Journal of Functional Foods 2019, 52, 537-544. (SCI期刊)
  21. Hsu, M. J.; Peng, S. F.; Chueh, F. S.; Tsai, C. H.; Tsai, F. J.; Huang, C. Y.; Tang, C. H.; Yang, J. S.; Hsu, Y. M.; Huang, W. W.; Chung, J. G., Lupeol suppresses migration and invasion via p38/MAPK and PI3K/Akt signaling pathways in human osteosarcoma U-2 OS cells. Bioscience Biotechnology and Biochemistry 2019, 83 (9), 1729-1739. (SCI期刊)
  22. Chen, C. C.; Chueh, F. S.; Peng, S. F.; Huang, W. W.; Tsai, C. H.; Tsai, F. J.; Huang, C. Y.; Tang, C. H.; Yang, J. S.; Hsu, Y. M.; Yin, M. C.; Huang, Y. P.; Chung, J. G., Cantharidin decreased viable cell number in human osteosarcoma U-2 OS cells through G(2)/M phase arrest and induction of cell apoptosis. Bioscience Biotechnology and Biochemistry 2019, 83 (10), 1912-1923. (SCI期刊)
  23. Chang, C. H.; Fu, J. H.; Su, C. H.; Yin, M. C.; Hsu, Y. M.*, Four spices prevent mice from contracting Salmonella enterica serovar Typhimurium. Experimental and Therapeutic Medicine 2019, 18 (4), 2956-2964. (SCI期刊)
  1. NSTC 112-2320-B-029 -001-MY3，雷曼氏乳酸桿菌所衍生之後生元透過調控胃上皮細胞脂筏形成對抗胃幽門螺旋桿菌感染之作用機制探討，國科會，2023/8/1~2026/7/31。
  2. MOST 109-2320-B-039-009-MY3，探討乳製品中之雷曼氏乳酸桿菌藉由細胞溝通機制影響胃幽門螺旋桿菌致病性之作用機轉，科技部，2020/8/1~2023/7/31。
  3. MOST 106-2320-B-039-044-MY3，探討乳製品中之雷曼氏乳酸桿菌抑制胃幽門螺旋桿菌感染之作用機制，科技部，2017/8/1~2020/07/31。
  4. MOST 105-2320-B-039-039，以功能性食材與乳酸菌治療胃幽門螺旋桿菌感染之作用機制與其交互作用之探討，科技部，2016/8/1~2017/7/31。
  5. NSC 102-2313-B-039-003-MY3，探討梔子素與益生菌用於對抗幽門螺旋桿菌感染之離體及活體分子作用機轉，國科會，2013/8/1~2016/7/31。
  1. 改善犬隻消化與異位性皮膚炎之益生菌與中草藥複方組合，福壽實業股份有限公司，2017.1 ~2021.12。
  2. 防止仔豬下痢之益生菌與中草藥組合配方，祥圃實業股份有限公司，2015.2 ~ 2020.2。
  3. 治療肝炎及／或癌症的醫藥組合物 A PHARMACEUTICAL COMPOSITION FOR TREATING HEPATITIS AND/OR CANCER，發明專利，台灣，201320996(TWI430792)，2014.3.21 ~ 2031.11.16。
  4. 篩選生物活性轉換酵素之最適化菌株，鴻元生技股份有限公司，2009.4 ~ 2016.3。
  5. 天然藍色食用色素之量產技術，鴻元生技股份有限公司，2010.1 ~ 2015.12。
  6. 雞副嗜血桿菌外膜蛋白表現技術，台灣生物製劑股份有限公司，2006.5 ~ 2009.5。
  1. Jong-Tsun Huang (黃榮村) and Yuan-Man Hsu (徐媛曼). Chapter 14: Challenges and Prospects for Taiwan’s Higher Education. Higher Education in Taiwan Global, Political and Social Challenges and Future Trends. pp 256-268, Springer, 2020.12.30. (ISBN 978-981-15-4554-2)
  2. Ho-Sheng Wu , Tsai-Chung Li , Shu-fang Li , Ruwen Jou, Yuan-Man Hsu, Jia-Horng Kao, Kow-Tong Chen, Lu-Hung Chen , Yi-Chen Yang, Ji-Rong Yang, Ming-Jeng Pan, Ying-Hen Hsieh, Ming-Rong Harn, Yu-Ching Lan. Infectious Diseases in Taiwan. China Medical University, 2013.08. (ISBN:978-986-6778-39-1)
  3. 吳和生、李采娟、李淑芳、周如文、徐媛曼、高嘉宏、張筱玲、陳國東、陳陸宏、楊依蓁、楊季融、潘銘正、謝英恒、韓明榮、藍郁青，臺灣常見傳染病學。中國醫藥大學，2012.12。(ISBN:978-986-6778-38-4)
  4. 吳錫金、侯庭鏞、方世華、林振文、項千芸、李龍緣、林應如、許晉銓、萬磊、徐媛曼、洪千惠、湯智昕、賴怡琪、賴志河，生物資訊/Arthur M. Lesk（著），2008.09。(ISBN:978-986-6929-12-0)
  5. 李龍緣、林應如、洪千惠、許晉銓、方世華、萬磊、湯智昕、賴志河、徐媛曼、林振文、項千芸，醫護微生物及免疫學 (第三版)，新文京開發出版股份有限公司，2008.04。(ISBN:978-986-150-819-1)
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