朱自淳 副教授

Ju, Tz-Chuen

信箱:tzchuen@thu.edu.tw

朱自淳(第四家族)Ju, Tz-Chuen
職稱
Title
副教授
Associate Professor
學生訪談時間
Students time
星期三 9:00~12:00
Wed. 9:00~12:00
聯絡方式
Contact
Tel: 886-04-23590121轉37120或37100
Fax: 886-04-23590385 
E-mail:tzchuen@thu.edu.tw
學經歷
Background
國立陽明大學神經科學研究所博士
Ph.D. in Institute of Neuroscience, National Yang-Ming University
慈濟大學神經科學研究所碩士
Master in Institute of Neuroscience, Tzu Chi University
國立宜蘭大學畜產學系學士
Bachelor in Department of Animal Science, National I-Lan University
研究方向
Research
神經科學、神經退化性疾病、細胞訊息傳遞、發炎與代謝症候群
Neuroscience、Neurodegenerative Disease、Signal Transduction、inflammatory response in Metabolic syndrome
授課名稱
Course
大學部 Undergraduate Program
家畜解剖生理學 (2-2)
Anatomy & Physiology of Domestic Animals (2-2)
代謝生理學 (2-0)
Metabolic Physiology (2-0)
動物科學概論 (2-0)
Introduction of animal science (2-0)
基礎動物學 (3-0)
Fundamentals of Zoology (3-0)

研究所 Graduate Program
神經科學 (3-0)
Neuroscience (3-0)
動物組織學 (2-0)
Animal Histology (2-0)
神經系統疾病 (0-2)
Diseases of Nervous System (0-2)
動物科學研究法(0-2)
Methodology of Animal Science (0-2)
  1. Chen, K. P.#, Hua, K. F.#, Tsai,F. T., Lin, T. Y., Cheng, C. Y., Yang, D. I., Hsu, H. T., and Ju, T. C.* (2022, Feb). A selective inhibitor of the NLRP3 inflammasome as a potential therapeutic approach for neuroprotection in a transgenic mouse model of Huntington’s disease. Journal of Neuroinflammation. 26; 19(1): 56. (SCI/IF: 8.322; Neuroscienc, 23/273=8.4 %)
  2. Hua, K. F.#, Chao, A. C.#, Lin, T. Y., Chen, W. T., Lee, Y. C., Hsu, W. H., Wang, H. M., Lee, S. L., Yang, D. I., and Ju, T. C.* (2021, Nov). Ginsenoside compound K reduces the progression of Huntington’s disease via the inhibition of oxidative stress and overactivation of the ATM/AMPK pathway. Journal of Ginseng Research. 64: 1-13. (SCI/IF: 6.060; Integrative & Complementary Medicine, 1/29=3.4%)
  3. Ho, C. L., Lin, C. L., Li, L.H., Hua, K. F., Ju, T.C.* (2021, Oct). Inhibition of pro-inflammatory mediator expression in macrophages using wood vinegar from Griffith’s ash. Chinese Journal of Physiology. 64(5):232–243. (SCI/IF: 1.764; Physiology, 71/86=82.6%)
  4. T. C. Ju, Y. C. Liao, K. P. Chen, Y. J. Kai, Y. H. Chen and S. K. Yang.* (2021, Feb). Nocturnal light pulse stimulates gonadal development and lowers fat deposition in male mule ducks. Animals. 11 (4): 614 – 622. (SCI/IF: 2.752; Agriculture, dairy& animal Science, 13/63=20.6 %)
  5. Ho, C. L., Li, L.H., Weng, Y. C., Hua, K. F., Ju, T.C.* (2020, Jun). Eucalyptus essential oils inhibit the lipopolysaccharide-induced inflammatory response in RAW264.7 macrophages through reducing MAPK and NF-κB pathways. BMC Complementary Medicine and Therapies. 20 (1): 200. (SCI/IF: 3.47; Complementary and Alternative Medicine, 9/83=24 %)
  6. Li, L.H., Chen, T. L., Chiu, H. W., Hsu, H. H., Wang, C. C., Tai, T. T., Ju, T. C., Chen, F. H., Chernikov O.V., Tsai., W. C., and Hua, K. F.* (2020). Critical Role for the NLRP3 Inflammasome in Mediating IL-1β Production in Shigella sonnei-Infected Macrophages. Frontiers in Immunology. 11: 1–14. (SCI/IF: 4.716; Immunology, 44/158=28 %)
  7. Hsieh, C.Y., Li, L.H., Lam Y., Fang, Z., Gan, C. H., Rao, Y. K., Chiu, H. W., Wong, W. T., Ju, T.C., Chen, F.H., Chernikov O.V., Liu, M. L., Hsu,C.H., and Hua, K. F.* (2020). Synthetic 4-Hydroxy Auxarconjugatin B, a Novel Autophagy Inducer, Attenuates Gouty Inflammation by Inhibiting the NLRP3 Inflammasome. Cells. 9(2): 1–17. (SCI/IF: 4.829; Cell Biology, 55/190=29 %)
  8. Li, L.H., Lin, J.S., Chiu, H.W., Lin, W.Y., Ju, T.C., Chen, F.H., Chernikov O.V., Liu, M.L., Chang, J.C., Hsu, C.H., Gao, H.W., Hua, K. F.* (2019). Mechanistic insight into the activation of the NLRP3 inflammasome by Neisseria gonorrhoeae in macrophages. Frontiers in Immunology. 10:1–18. (SCI/IF: 4.716; Immunology, 44/158=28 %)
  9. Hsieh, C.Y., Li, L.H., Rao, Y.K., Ju, T.C., Nai, Y.S., Chen, Y.W. , Hua, K. F. (2019). Mechanistic insight into the attenuation of gouty inflammation by Taiwanese green propolis via inhibition of the NLRP3 inflammasome. Journal of Cellular Physiology. 234(4):4081–4094. (SCI/IF: 4.522; Physiology, 11/81=14%)
  10. Wu, H.Y., Yang, F.L., Li,L.H., Rao, Y.K., Ju, T.C., Wong, W.T., Hsieh, C.Y., Machael Pivkin, Hua, K. F., Wu,S.H. (2018). Ergosterol peroxide from marine fungus Phoma sp. induces ROS dependent apoptosis and autophagy in human lung adenocarcinoma cells. Scientific Reports.8:17956. (SCI/IF: 4.12; Multidisciplinary Sciences, 15/69=22%)
  11. Ju, T.C.,# Li, L.H.#, Dong, W. C., Hua, K. F.,* Chen, W. J.* (2017) A synthetic cationic antimicrobial peptide inhibits inflammatory response and the NLRP3 inflammasome by neutralizing LPS and ATP. PLOS ONE. 12(7):e0182057. (SCI/IF: 2.776; Multidisciplinary Science, 15/64=23%)
  12. Liu, Y.J., Ju, T.C., Chen, H.M., Jang, Y.S., Lee, L.M., Lai, H.L., Tai, H.C., Fang, J.M., Lin, Y.L., Tu, P.H. , and Chern, Y. (2014) Activation of AMP-activated protein kinase a1 mediates mislocalization of TDP-43 in amyotrophic lateral sclerosis. Human Molecular Genetics. 24: 787–801. (SCI/IF: 4.544; Molecular Biology & Genetics, 18/297=6%)
  13. Ju, T.C., Chen, H.M., Chen, Y.C., Chang, C., and Chern, Y.* (2014) AMPK-1 functions downstream of oxidative stress to mediate neuronal atrophy in Huntington’s disease. Biochimica et Biophysica Acta-Molecular Basis of Disease. 1842: 1668–1689. (SCI/IF: 4.328; Biochemistry & Molecular Biology, 45/290=16%)
  14. Ju, T.C., Lin, Y.S., and Chern, Y.* (2012) Energy dysfunction in Huntington’s Disease: Insights from PGC-1α, AMPK and CKB. Cellular and Molecular Life Sciences. 69: 4107–4120. (SCI/IF: 5.788; Biochemistry & Molecular Biology, 40/290=14%)
  15. Ju, T.C., Chen, H.M., Lin, J.T., Chang, C.P., Chang, W.C., Kang, J.J., Sun, C.P., Tao, M.H., Tu, P.H., Chang, C., Dickson, D.W., and Chern, Y.* (2011) Nuclear translocation of AMPK-α1 potentiates striatal neurodegeneration in Huntington’s disease. Journal of Cell Biology. 194: 209–227. (SCI/IF: 8.984; Cell Biology, 27/190=14%). Highlighted by a commentary in the same issue of JCB)
  16. Ju, T.C., Chen, S.D., Liu, C.C., and Yang, D.I* (2005) Protective effects of S-nitrosoglutathione against amyloid beta-peptide neurotoxicity. Free Radical Biology and Medicine. 38: 938–949. (SCI/IF: 5.606; Biochemistry & Molecular Biology, 42/290=14%)
  17. Yang, Y.T., Ju, T.C., and Yang, D.I* (2005) Induction of hypoxia inducible factor-1 attenuates metabolic insults induced by 3-nitropropionic acid in rat C6 glioma cells. Journal of Neurochemistry. 93: 513–525. (SCI/IF: 4.083; Biochemistry & Molecular Biology, 77/290=27%)
  18. Ju, T.C., Yang, Y.T., and Yang, D.I* (2004) Protective effects of S-nitrosoglutathione against neurotoxicity of 3-nitropropionic acid in murine neurons. Neuroscience Letters. 362: 226–231. (SCI/IF: 2.180; Neuroscience, 180/259=69%)
  19. Yang, D.I, Yin, J.H., Ju, T.C., Chen, L.S., and Hsu, C.Y.* (2004) Nitric oxide and BCNU chemoresistance in C6 glioma cells: role of S-nitrosoglutathione. Free Radical Biology and Medicine. 36: 1317–1328. (SCI/IF: 5.606; Biochemistry & Molecular Biology, 42/290=14%)
  20. Yang, D.I, Chen, S.D., Yang, Y.T., Ju, T.C., Xu, J.M., and Hsu, C.Y.* (2004) Carbamoylating chemoresistance induced by cobalt pretreatment in C6 glioma cells: putative roles of hypoxia inducible factor-1. British Journal of Pharmacology. 141: 988–996. (SCI/IF: 5.491; Pharmacology & Pharmacy, 19/257=7.4%)
  1. Ting-Yu Lin and Tz-Chuen Ju.* (2022) Ginsenosidecompound K reduces the progression of Huntington’s disease via the inhibition of oxidative stress and overactivationof the ATM/AMPK pathway. Merck Young Scientist Award TAIWAN, Taiwan.
  2. Chih-Yuan Cheng and Tz-Chuen Ju.* (2022) A selective inhibitor of the NLRP3 infammasome as a potential therapeutic approach for neuroprotection in a transgenic mouse model of Huntington’s disease. Merck Young Scientist Award TAIWAN, Taiwan.
  3. Ting-Yu Lin, Kuo-Feng Hua, Wan-Tze Chen, Ding-I. Yang and Tz-Chuen Ju.* (2022) Ginsenosidecompound K reduces the progression of Huntington’s disease via the inhibition of oxidative stress and overactivationof the ATM/AMPK pathway. The 36nd Joint Annual Conference of Biomedical Sciences, Taipei, Taiwan.
  4. Yu-Jun Chang, Kuo-Feng Hua, Tz-Chuen Ju.* (2019) Investigation of the protective effect of Citral against gout-associated uric acid crystals. International Conference on Pharmaceutical Chemistry, Thailand.
  5. Ding-I Yang and Tz-Chuen Ju.* (2018) Beneficial effects of polysaccharides extracted from local Basella spp. promotion of wound-healing. International Forum – Agriculture, Biology, and Life Science-Summer Session, Japan
  6. Wan-Tze Chen, Ding-I Yang and Tz-Chuen Ju.* (2017) Beneficial effects of polysaccharides extracted from local Basella spp. promotion of wound-healing. Annual Symposium on Medical Nursing and Health Technology, Taiwan.
  7. Tz-Chuen Ju. * (2017) Eucalyptus essential oils inhibit inflammatory responses in LPS-activated macrophages. Annual Symposium on Medical Nursing and Health Technology, Taiwan.
  8. Tz-Chuen Ju.* (2016) AMPK Facilitate DNA Damage in Huntington’s Disease. Annual Symposium on Medical Nursing and Health Technology, Taiwan.
  9. Tz-Chuen Ju.* (2015) Molecular determinants of cellular energy homeostasis and DNA damage in Huntington’s disease. The 39th Annual Meeting of the Japan Neuroscience Society, Japan

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