柯孟韡助理教授

柯孟韡(第七家族)	Ke, Meng-Wei
職稱 Title	助理教授 Assistant Professor
學生訪談時間 Students time	星期三 9:00~12:00 Wed. 9:00~12:00
聯絡方式 Contact	Tel: 886-04-23590121轉37123 Fax: 886-04-23590385 E-mail: dinoke@thu.edu.tw

學經歷 Background	國立臺灣大學動科所博士 Doctor of Philosophy, Department of Animal Science and Technology, National Taiwan University 國立臺灣大學動科所碩士 Master Degree, Department of Animal Science and Technology, National Taiwan University 國立臺灣大學畜產系學士 Bachelor Degree, Department of Animal Science, National Taiwan University
研究方向 Research	乳腺發育與泌乳分子調控 (the mechanism of mammary gland development and lactation) 幹細胞於疾病治療之應用 (the application of stem cell in disease) 肺動脈高壓疾病之分子機制與治療 (the molecular mechanism and novel treatment of pulmonary arterial hypertension) 肺纖維化疾病之分子機制與治療 (the molecular mechanism and novel treatment of idiopathic pulmonary fibrosis) 飼料添加劑與動物生長性能表現 (feed additives and the performance of domestic animals)
授課名稱 Course	大學部 Undergraduate Program 家畜解剖生理學 (2-2) Anatomy & Physiology of Domestic Animals (2-2) 基礎動物學 (3-0) Fundamentals of Zoology (3-0) 動物福祉 (2-0) Animal Welfare (2-0) 豬學 (2-0) Swine Production (2-0) 實驗動物學 (2-0) Laboratory Animal Science (2-0) 幹細胞學概論 (2-0) Introduction to Stem Cells (2-0) 動物營養學(0-3) Animal Nutrition(0-3) 研究所 Graduate Program 泌乳生理學(0-2) Physiology of Lactation(0-2)

Pei-Ling Chi, Chin-Chang Cheng, Cheng-Chung Hung, Mei-Tzu Wang, Hsien-Yueh Liu, M. W. Ke, Min-Ci Shen, Kun-Chang Lin, Shu-Hung Kuo, Pin-Pen Hsieh, Shue-Ren Wann, Wei-Chun Huang. (2022) MMP-10 from M1 macrophages promotes pulmonary vascular remodeling and pulmonary arterial hypertension. Int. J. Biol. Sci. 18(1): 331-348.
W. C. Huang, M. W. Ke (joint first author), C. C. Cheng, S. H. Chiou, S. R. Wann, C. W. Shu, K. R. Chiou, C. J. Tseng, H. W. Pan, G. Y. Mar, C. P. Liu. (2016) Therapeutic Benefits of Induced Pluripotent Stem Cells in Monocrotaline-Induced Pulmonary Arterial Hypertension. PLoS ONE 11(2):e0142476.
M. W. Ke, J. T. Hsu, Y. N. Jiang, W. T. K. Cheng and Y. T. Ju. (2012) Characterization of hTERT-immortalized caprine mammary epithelial cells. Reprod. Domest. Anim. 47(4):553-561.
M. W. Ke, Y. N. Jiang, Y. H. Li, T. Y. Tseng, M. S. Kung, C. S. Huang, W. T. K. Cheng, J. T. Hsu and Y. T. Ju. (2007) Development and Characterization of a Specific Anti-Caveolin-1 Antibody for Caveolin-1Functional Study in Human, Goat and Mouse. Asian-Aust. J. Anim. Sci. 6:856-865.
Y. N. Jiang, Y. H. Li, M. W. Ke, C. Y. Huang, T. Y. Tseng, Y. B. Tang, M. C. Huang, C. K. J. Shen and Y. T. Ju. (2007) Caveolin-1 Sensitizes Rat Pituitary GH3 Cells to Bromocriptine Induced Apoptosis. Cancer Cell Int. 7:1.

M. W. Ke, W. C. Huang, C. C. Cheng, S. H. Chiou, S. R. Wann, C. W. Shu, K. R. Chiou, C. J. Tseng, G. Y. Mar, C. P. Liu. (2015)。Therapeutic potential of induced pluripotent stem cells in monocrotaline-induced pulmonary arterial hypertension。
M. W. Ke, C. C. Cheng, W. C. Huang, S. R. Wann, C. W. Shu, G. Y. Mar, C. P. Liu, C. J. Tseng. (2016)。Caffeic acid phenethyl ester ameliorates monocrotaline-induced pulmonary arterial hypertension through inhibiting Erk/NF-kB/Hif-1a signaling pathway。

M. W. Ke, W. C. Huang, C. C. Cheng, M. C. Sheng, T. J. Li, W. T. Huang, C. W. Hsu, S. R. Wann, Y. T. Chang, G. Y. Mar, C. P. Liu. (2016)。Induced-pluripotent stem cells-derived conditioned medium attenuates the inflammation in E. coli-induced sepsis。
M. W. Ke, C. C. Cheng, W. C. Huang, C. W. Hsu, S. R. Wann, M. C. Sheng, T. J. Li, W. T. Huang, Y. T. Chang, G. Y. Mar, C. P. Liu, C. J. Tseng. (2016)。Caffeic acid phenethyl ester attenuates pulmonary arterial hypertension in rat through inhibiting the Hif-1a mediated PDGF signaling。
M. W. Ke, W. C. Huang, C. C. Cheng, S. R. Wann, C. J. Tseng. (2016)。Pro-inflammatory macrophage regulates MMP1 and MMP10 expression in pulmonary arterial hypertension via the ERK and JNK signal pathways。

柯孟韡、王翰聰、徐濟泰 (2002)。Fibrobacter succinogenes S85纖維分解酵素之純化與特性探討。31(4) : 268。《論文新人獎》。
柯孟韡、朱有田、姜延年、黃木秋 (2004)。不朽山羊乳腺上皮細胞株之建立。33(增刊) : 63。
柯孟韡、曾亭育、姜延年、朱有田 (2004)。建立可供實驗應用之caveolin-1多株抗體。33(增刊) : 181。

M. W. Ke, T. Y. Tseng, Y. N. Jiang and Y. T. Ju (2004). Establishment of a polyclonal caveolin-1 antibody for cancer diagnosis.
M. W. Ke, L. S. Wu, Y. L. Jiang and Y. T. Ju (2005). Establishment of lacto-hormone inducible immortal caprine mammary epithelial cell line.

Anti-Caveolin-1 Polyclonal Antibody, and Antigen Peptide Sequence and Method for Preparation the Same (U.S. patent Application No. 12/081520)

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