育種與神經科學實驗室
(BBQ Lab)
Breeding, Brain & PolyQ Laboratory
(BBQ Lab)
負責老師：陳怡蓁助理教授、童志偉助理教授
Advisors: Assistant Professor Chen, Yi-Chen and Assistant Professor Chih-Wei Tung
本實驗室結合動物育種、細胞生物學、分子生物學及神經科學等研究領域，從動物個體表型至細胞與分子層級探討重要生物學問題。目前研究方向包括數位育種、畜產品來源細胞外囊泡對肌肉生長與發炎反應之調控，以及 polyglutamine（polyQ）相關神經退化性疾病之分子機制。透過跨領域研究方法，期望建立從動物生產、生物科技至疾病機制研究的整合性研究平台。
The BBQ Laboratory integrates animal breeding, cell biology, molecular biology, and neuroscience to investigate biological questions ranging from animal phenotypes to cellular and molecular mechanisms. Our current research focuses on digital breeding, the regulatory effects of livestock-derived extracellular vesicles on skeletal muscle growth and inflammation, and the molecular mechanisms underlying polyglutamine (polyQ)-related neurodegenerative diseases. Through interdisciplinary approaches, we aim to establish an integrated research platform connecting animal production, biotechnology, and disease biology.
主要研究方向
Research Areas
1. 數位育種：結合動物育種、影像分析、人工智慧及數據科學技術，建立動物表型量化與智慧化育種方法，以提升育種效率及動物生產管理之精準度。
1. Digital Breeding: We integrate animal breeding with image analysis, artificial intelligence, and data science to develop quantitative phenotyping and precision breeding approaches for improving breeding efficiency and animal production management.
2. 畜產品來源細胞外囊泡對肌肉生長及發炎反應之調控機制：探討乳品等畜產品來源之細胞外囊泡（extracellular vesicles, EVs）對骨骼肌生長、氧化壓力及發炎反應之影響，並解析其相關細胞與分子訊息傳遞機制。
2. Regulatory Effects of Livestock-Derived Extracellular Vesicles on Muscle Growth and Inflammation: We investigate how extracellular vesicles (EVs) derived from livestock products, particularly milk, regulate skeletal muscle growth, oxidative stress, and inflammatory responses, with an emphasis on the underlying cellular and molecular signaling mechanisms.
3. Polyglutamine（polyQ）類型神經退化性疾病中蛋白質聚集之分子機制：以細胞、線蟲及動物模式探討 polyQ 蛋白質聚集、蛋白質恆定性失衡及神經退化之分子機制，並尋找可能調控蛋白質聚集及神經功能之分子與治療策略。
3. Molecular Mechanisms of Protein Aggregation in Polyglutamine (polyQ)-Related Neurodegenerative Diseases: Using cellular, C. elegans, and animal models, we investigate the molecular mechanisms underlying polyQ protein aggregation, disruption of proteostasis, and neurodegeneration, and explore potential molecular targets and therapeutic strategies for modulating protein aggregation and neuronal function.
