歐柏榮 教授

Ou, Bor-Rung

Email：brou@thu.edu.tw
Tel：+886-4-23590121  #37129

歐柏榮(第一家族)Ou, Bor-Rung
職稱
Title		教授
Professor
學生訪談時間
Students time		週四 15:00~17:00
Thursday 15:00~17:00
聯絡方式
Contact		Tel: 886-04-23590121-37129
Fax: 886-04-23590385
E-mail: brou@thu.edu.tw
學經歷
Background		東海大學生物學系
美國奧立岡州立大學碩士
美國奧立岡州立大學博士
Tunghai University, Department of Biology, BS
Oregon State University, Department of Animal Sciences, MS
Oregon State University, Department of Animal Sciences, Ph.D.
研究方向
Research		肌肉發育與生長 
( Development and growth of skeletal muscle )
細胞基因調控機制 
( Regulation of gene expression in skeletal muscle ) 
基因轉殖畜產動物之產製 
( Production of transgenic animal ) 
水產及畜產動物致病源之檢驗方法之研發 
( Diagnosis of pathogen in aquatic organisms )
授課名稱
Courses		Introduction to Molecular Biology (0-2)
免疫學(3-0) 
Immunology (3-0) 
現代生物科技 (2-0), (0-2) 
Modern Biotechnology (2-0), (0-2)
分子生物學特論(2-0) 
Special Topic of Molecular Biology (2-0) 
動物細胞培養 (2-0)
Animal Cell Culture (2-0)

一、骨骼肌肉的生長與發育：

　(1)依鈣蛋白質分解酵素 (calpain) 在骨骼肌生長與分化所扮演的角色

　(2)myostatin (growt/differentiation-8)對骨骼肌發育的影響

　(3)鹿茸對動物骨骼肌肉生長與分化的影響

二、利用益生菌表現外源性重組蛋白質

三、土雞繁殖力功能性基因體研究。

四、水產及畜產動物病原菌及病毒檢驗試劑之研發。

  • Yeh, J. Y., Cheng, L. C., Ou, B. R., Whanger, P. D. and Chang, L. W. 2002. Differential influences of various arsenic compounds on glutathione redox status and antioxidative enzymes in porcine endothelial cells. Cell. Mol. Life Sci. 59: 1972-1982. (SCI)
  • Horng, D. C., Huang, H. W., Liang, Y. C. and Ou, B. R. 2003. Two distinct phylogenetic groups of Formosan Serow (Naemorhedus swinhoei Gray) population in Taiwan: base on mitochondrial D-loop region sequences Endemic Species Research. 5:15-25.
  • Liang, Y. C., Yeh, J. Y. and Ou, B. R. 2003. Over-expression of porcine growth/differentiation factor 8 recombinant protein in baculovirus expression system. J. of Chinese Society of Animal Science 32: 23-32.
  • Han, G. H., Ou, B. R. and Yang, S. K. 2003. Use of polymerase chain reaction for sexing Formosa sika deer. J. of Chinese Society of Animal Science 32:215-227.
  • Yeh, J. Y., Cheng, L. C., Liang, Y. C. and Ou, B. R. 2003. Modulation of the arsenic effects on cytotoxicity, viability, and cell cycle in porcine endothelial cells by selenium. Endothelium 10:127-139. (SCI)
  • Lin, Y. J., Ou, B. R. and Kuo, C. C. 2003. Quality characteristics of duck breast muscle as affected by calcium chloride and post-mortem storage. Taiwanese Journal of Agricultural Chemistry and Food Science 41:387-397.
  • Chung, T. C., Liang, Y. C., Yeh, J. Y. and Ou, B. R. 2004. Stabilization of calpain large subunits by overexpression of truncated calpain small subunit in L8 myoblasts. Tissue & cell 36:181-187. (SCI)
  • Shie, D. Y., Ou, B. R. and Kuo, C. C. 2005. Tenderness and calpain activity of goose breast muscles as affected by calcium chloride. Taiwanese Journal of Agricultural Chemistry and Food Science 43(2): 108-114.
  • Yang, K. T., Lin, C. Y.,Chien, C. Y., Wu, C. P., Huang, C. W., Ou, B. R., Chen, C. F., Lee, Y. P., Lee, W. C., Lin, E. C., Ding, S. T., Cheng, W. T. K. and Huang, M. C. 2006. Effects of relative humidity, dot space, printing solution and slide coating on the dot morphology of gene chips. J. of Chinese Society of Animal Science 35(3): 145-151.
  • Liang, Y. C., Yeh, J. Y., Forsberg, N. E. and Ou, B. R. 2006. Involvement of mu- and m-calpains and protein kinase C isoforms in L8 myoblast differentiation. International Journal of Biochemistry and Cell Biology. 38(4):662-70. (SCI)
  • Yeh, J. Y., Ou, B. R., Liang, Y. C., Burchfiel, J., Butler, J. A., Forsberg, N. E. and Whanger, P. D. 2006. Mechanism for proliferation inhibition by various selenium compounds and selenium-enriched broccoli extract in rat glial cells. Biometals 19:611-621. (SCI)
  • Cheng, C. H., Ou, B. R., Shen, T. F. and Ding, S. T. 2006. Effects of dietary Algal Docosahexaenoic acid oil supplement on fatty acid deposition and gene expression in laying Tsaiya ducks. Asian-Aust. J. Anim. Sci. 19(7): 1047-1053. (SCI)
  • Teng, P. H., Lee, P. Y., Lee, F. C., Chien, H. W., Chen, M. S., Sung, P. F., Su, C. and Ou, B. R. 2006. Detection of infectious hypodermal and hematopoietic necrosis virus (IHHNV) in Litopenaeus vannamei by ramification amplification assay. Disease of Aquatic Organisms 73:103-111. (SCI)
  • Teng, P. H., Chen, C. L., Wu, C. N., Wu, S. Y., Ou, B. R. and Lee, P. Y. 2006. Rapid and sensitive detection of Taura syndrome virus using nucleic acid-based amplification. Disease of Aquatic Organisms 73: 13-22.
  • Liang, Y. C., Yeh, J. Y. and Ou, B. R. 2007 Effect of maternal myostatin antibody on offspring growth performance and body composition in mice. Journal of Experimental Biology. 210:477-483. (SCI)
  • Tsai, S. H., Liu, Y. W., Tang W. C., Zhou, Z. W., Hwang, C. Y., Ou, B. R., Hu, C. P., Yang, V. C. And Chen, J. K. 2007. Characterization of porcine arterial endothelial cells cultured on amniotic membrane, a potential matrix for vascular tissue engineering. Biochemical and Biophysical Research Communication. 15;357(4):984-90. (SCI)
  • Teng, P. H., Chen, C. L., Sung, P. F., Lee, F. C. Ou, B. R., and Lee, P. Y. 2007. Specific detection of reverse transcription-loop-mediated isothermal amplification amplicons for Taura syndrome virus by colorimetric dot-blot hybridization. Journal of Virological method 140:317-326. (SCI)
  • Ding, S. T., Ko, Y. H., Ou, B. R., Wang, P.H., Huang, M. C., Lee, Y. P., Lin, E.C., Chen, C. F., Lin, H.W. and Cheng W. T. K. 2008. The expression of genes related to egg production in the liver of Taiwanese country chickens. Asian-Aust. J. Anim. Sci. 21 (1) : 19 (SCI)
  • Yang, K. T., Lin, C. Y., Huang, H. L., Liou, J. S., Chien, C. Y., Wu, C. P., Huang, C. W., Ou, B. R., Chen, C. F., Lee, Y. P., Lin, Lin, E. C., Tang, P. C., Lee, W. C., Ding, S. T., Cheng, W. T. K., and Huang, M. C. 2008 Feb. Expressed transcripts associated with high rates of egg production in chicken ovarian follicles. Molecular Cellular probes 22(1):47-54.
  • Cheng, Y. H., Ou, B. R., Cheng, L. C., Lu, J. H. and Yeh, J. Y.* (2008.12) Glutathione regulation in arsenic-induced porcine aortic endothelial cells. Toxicology in Vitro 22(8):1832-1839. (SCI)
  • Hsu, K. H., Pei, C., Yeh, J. Y., Shih, C. H., Chung, Y. C., Hung, L. T., and Ou, B. R. 2009. Production of bioactive human α-defensin 5 in Pichia pastoris. J. Gen. Appl. Microbiol. 55:395-401.
  • Charles, L., Yeh, J. Y., Huang, T. C., Ou, B. R. 2010 Editors: Clarence S. Hollingworth. Food Hydrocolloids: Characteristics, Properties and Structures: The Influence of Structural Properties and Biological Functions of Sweet Cassava and Seaweed Polysaccharides;pp. 179-203.
  • B. R. Ou, M. J. Jiang, C. H. Lin, Y. C. Liang, K. j. Lee and J. Y. Yeh. 2010. Characterization and expression of chicken selenoprotein W. Biometals 24(2):323-33.
  • Cheng-Fang Tsai, Bor-Rung Ou, Yu-Chuan Liang, Jan-Ying Yeh. 2013. Growth inhibition and antioxidative status induced by seleniumenriched broccoli extract and selenocompounds in DNA mismatch repairdeficient human colon cancer cells. Food Chemistry 139:267-273.
  • Ahmed, H. M. M., Yeh, J. Y., Lin, W. J., Forsberg, N. E., Cheng, W. T. K., Ou, B. R. 2014. Validation of a luciferase bioassay to detect the progestative activity in gilts whose estrus was induced by an uterotonic herb (Ligusticum chuanxiong) Livestock Science 163:159-164.
  • Yun-Long Tsai, Han-Ching Wang, Chu-Fang Lo, Kathy Tang-Nelson, Donald Lightner, Bor-Rung Ou, Ai-Ling Hour, Chuan-Fu Tsai, Cheng-Chi Yen, Hsiao-Fen Grace Chang, Ping-Hua Teng, Pei-Yu Lee. 2014. Validation of a Commercial Insulated Isothermal PCRbased POCKIT Test for Rapid and Easy Detection of White Spot Syndrome Virus Infection in Litopenaeus vannamei. PLOS ONE March 2014 | Volume 9 | Issue 3 | e90545
  • H. M. Manir Ahmed, Jan-ying Yeh, Yi-Chia Tang,Winston Teng-Kuei Cheng, Bor-Rung Ou. 2014. Molecular screening of Chinese medicinal plants for progestogenic and anti-progestogenic activity. J. Bioscience 39(3): 453-461.

    Nileema R. Divate, Gen-Hung Chen, Pei-Ming Wang, Bor-Rung Ou (歐柏榮) & Yun-Chin Chung. 2016.Engineering Saccharomyces cerevisiae for improvement in ethanol tolerance by accumulation of trehalose.Bioengineered 7:445-458.(SCI)

    Nileema R. Divate, Gen-Hung Chen, Rupesh D. Divate, Bor-Rung Ou(歐柏榮) & Yun-Chin Chung.2017.Metabolic engineering of Saccharomyces cerevisiae for improvement in stresses tolerance.BIOENGINEERED 8(5):524-535.(SCI)

    Hsiang-Yun Tung, Wei-Chen Chen, Bor-Rung Ou(歐柏榮), Jan-Ying Yeh, Yeong-Hsiang Cheng, Ping-Hua Tsng, Ming-Hua Hsu, Ming-Shiun Tsai , Yu-Chuan Liang.2018.Simultaneous detection of multiple pathogens by multiplex PCR coupled with DNA biochip hybridization.Laboratory Animals 52(2):186-195.(SCI)

    Liu, K. C., Yang, S. K.(楊錫坤), Ou, B. R.(歐柏榮), Hsieh, M. H., Tseng, C. E., Chang, C. W., Chen, S. H.2019.Using Percutaneous Endoscopic Outside-In Technique to Treat Selected Patients with Refractory Discogenic Low Back Pain.Pain Physician 22(2):187-198.(SCI)
  • Cheng, L. C., Ou, B. R., Chang, L. W. and Yeh, J. Y. Modulation on the arsenic effects on cell proliferation, cell viability and cell cycle in porcine endothelial cells by selenium. The 17th Joint Annual Conference of Biomedical Science, Taipei, Taiwan R.O.C. 2002.
  • Yeh, J. Y., Cheng, L. C., Cheng, Y. H., Chang, L. W. and Ou, B. R. Differential influences of various arsenic compounds on glutathione redox status and antioxidative enzymes. The 4th Asian-Pacific Organization for Cell Biology Congress, Taipei, Taiwan R.O.C. 2002.
  • Liang, Y. C., Yeh, J. Y. and Ou, B. R. The role of porcine growth/differentiation factor 8 recombinant protein in muscle development. 2002. J. Clin. Soc. Anim. Sci. 31(4):174.
  • Cheng, L. C., Yeh, S. C., Ou, B. R., Cheng, Y. H., Chang, L. W. and Yeh, J. Y. Arsenic excretion in porcine aortic endothelial cells. The 18th Joint Annual Conference of Biomedical Science, Taipei, Taiwan R.O.C. 2003.
  • Hong, R. W., Wang, C. B., Yeh, J. Y. and Ou, B. R. Influence of serum factor on the differentiation of L8 myoblasts. 2003. J. Clin. Soc. Anim. Sci. 32 (Suppl.):193.
  • Yeh, J. Y., Whanger, P. D. and Ou, B. R. The involvement of hydrogen peroxide and glutathione peroxidase in cellular cytotoxicity induced by various selenium compounds. The 19th Joint Annual Conference of Biomedical Science, Taipei, Taiwan R.O.C. 2004.
  • Yeh, J. Y., Butler, J. A. and Whanger, P. D. (2004. 4) Growth inhibition, hydrogen peroxide levels and glutathione peroxidase activities induced by various selenium compounds and Se-enriched broccoli extract in cancer cells. Presented at the Experimental Biology Meeting in U.S.A.
  • Hsu, K. H., Wang, J. B., Huang, J. D., Hu, S. T., Chung, Y. C., Yeh, J. Y. and Ou, B. R. (2005. 3) The effect of dexamethasone on the expression of human defensin 5 in human lung large cell carcinoma. The 20th Joint Annual Conference of Biomedical Science (生物醫學聯合學術年會), Taipei, Taiwan R.O.C.
  • Yeh, J. Y., Butler, J. A., Liang, Y. C., Burchfiel, J., Ou, B. R. and Whanger, P. D. (2005. 4) Cell cycle, apoptosis and possible DNA damage induced by various selenium (Se) compounds and Se-enriched broccoli extract in rat glial cells. Presented at the Experimental Biology Meeting in U.S.A.
  • 江梅君、梁佑全、李孟修、歐柏榮、葉貞吟 (2005. 12) 土雞含硒蛋白W的選殖與組織中的表現。中國畜牧年會，台中，台灣。
  • 黃建德、鄧秉華、劉琳琳、葉貞吟、歐柏榮 (2005. 12) 不同品系豬種之第八生長分化因子基因啟動子多樣性。中國畜牧年會，台中，台灣。
  • 陳明軒、陳思樺、許恭豪、鄧秉華、葉貞吟、歐柏榮 (2005. 12) 利用精子載體法產製基因轉殖雞。中國畜牧年會，台中，台灣。
  • 曾柏澧、梁佑全、甯鈞慧、陳志峰、李淵百、葉貞吟、歐柏榮 (2005. 12) 台灣土雞鐵蛋白質基因之選殖及其與產蛋性能之關係。中國畜牧年會，台中，台灣。
  • Huang, T. Y., Yeh, J. Y., Ou, B. R. and Yang, S. K. (2006. 3) The effect of antler extract on the antioxidative status in HepG2 cell line. The 21th Joint Annual Conference of Biomedical Science (生物醫學聯合學術年會), Taipei, Taiwan R.O.C.
  • Hsu, K. H., Chen, S. H., Wang, J. B., Lee, M. S., Yeh, J. Y., Lee, S. D. and Ou, B. R. (2006. 3) Effect of exercise training on calpain systems in lean and obese Zucker rats. The 21th Joint Annual Conference of Biomedical Science (生物醫學聯合學術年會), Taipei, Taiwan R.O.C.
  • Yeh, J. Y., Butler, J.A., Ou, B. R., Forsberg, N. E. and Whanger, P. D. (2006.7) Mechanism for proliferation inhibition by various selenium compounds and selenium-enriched broccoli extract in rat embryonic fibroblasts. The 8th International Symposium on Selenium in Biology and Medicine, University of Wisconsin Madison, Wisconsin USA .July 25-July 30, 2006.
  • 黃泰元、葉貞吟、歐柏榮、王銘富、楊錫坤*。(2006.12) 添加臺灣梅花鹿鹿茸對早老化小鼠抗氧化酵素活性之影響。中國畜牧年會，台北，台灣。
  • 曾柏澧、梁佑全、葉貞吟、陳志峰、李淵百、歐柏榮*。(2006.12) 臺灣土雞含鐵蛋白及麩胱甘太S轉移酵素重組蛋白質與抗體之產製。中國畜牧年會，台北，台灣。
  • Yeh, J. Y., Jiang, M. J., Ou, B. R., Butler. J. A., Forsberg, N. E. and Whanger, P. D.* (2007.4) “Cloning and tissue distribution of chicken selenoprotein W”, Experimental Biology Meeting in Washington D. C., U.S.A.
  • 黃泰元、葉貞吟、歐柏榮、王銘富、楊錫坤*。(2007.12) 添加臺灣梅花鹿鹿茸對早老化小鼠抗氧化酵素基因表現之影響。中國畜牧年會，嘉義，台灣。中國畜牧年會(增刊) 36：200。
  • 林維哲、陳柏樺、葉貞吟、歐柏榮*。(2007.12) 免疫促進劑OmniGen AF對離乳仔豬存活率的影響。中國畜牧年會，嘉義，台灣。中國畜牧年會(增刊) 36：265。
  • 曾柏澧、李孟修、葉貞吟、丁詩同、趙清賢、陳志峰、李淵百、歐柏榮*。(2008.12) 雞隻血清中含鐵蛋白重鏈蛋白質與繁殖力之關係。中國畜牧年會，台北，台灣。
  • 王怡惠、林恩仲、王傳心、葉昌偉、謝昌煥、孫孝芳、黃木秋、丁詩同、邱繡河、歐柏榮、陳志峰、 李淵百、鄭登貴。(2008. 12) 台灣土雞表現序列標籤序列庫之分析與注解資料庫之建立。中國畜牧年會，台北，台灣。
  • 王怡惠、林恩仲、王傳心、葉昌偉、謝昌煥、孫孝芳、黃木秋、丁詩同、邱繡河、歐柏榮、陳志峰、 李淵百、鄭登貴。(2008. 12) 台灣土雞表現序列標籤序列庫之單一核?酸多型性的偵測。中國畜牧年會，台北，台灣。中國畜牧年會(增刊) 37。
  • 沈志隆、簡佑欣、張謙楷、葉貞吟、梁佑全、鄭登貴、陳志峰、李淵百、歐柏榮。(2009. 12) 第八生長分化因子基因調節區單核?酸多型態與雞隻產蛋性能之關係。中國畜牧年會，台北，台灣。中國畜牧年會(增刊) 38：156。
  • 梁佑全、許恭豪、李孟修、沈志隆、葉貞吟、歐柏榮。(2009. 12) 肌肉生長一志速在來亨蛋雞與台灣紅羽土雞的表現與短式肌肉生長抑制素的選殖與鑑定。中國畜牧年會，台北，台灣。中國畜牧年會(增刊) 38：206。
  • 黃俊凱、梁佑全、葉貞吟、歐柏榮。(2009. 12) 利用桿狀病毒表現系統表現斑馬魚細胞色素P4501B1蛋白質。中國畜牧年會，台北，台灣。中國畜牧年會(增刊) 38：207。
  • 沈志隆、葉貞吟、梁佑全、鄭登貴、陳志峰、李淵百、歐柏榮。(2010. 12) 。不同品系雞隻之肌肉生長抑制素基因調節區對其基因表現的影響。中國畜牧年會，台南，台灣。
  • 李孟修、林維哲、葉貞吟、梁佑全、鄭登貴、歐柏榮。(2010. 12) 肌肉生長抑制素及激活素對雞隻濾泡生成及繁殖性能之影響。中國畜牧年會，台南，台灣。
  • W. C. Chen, J. Y. Yeh, Y. C. Liang, W. T. K. Cheng and B. R. Ou, (2012. 12) Molecular cloning and characterization of poultry myostatins. 中國畜牧年會，台北，台灣。
    陳珮寧、周峻賢、陳憬輝、李彥勳、王愷雯、鄭登貴、歐柏榮。(2012. 12)「枯草桿菌木質纖維分解酵素基因之選殖與分析」中國畜牧年會，台北，台灣。
    H. M. M. Ahmed、陳冠?、唐翊家、鄭登貴、歐柏榮(2012. 12)「建立助孕素誘導冷光基因表現法以檢測助孕素及拮抗劑」中國畜牧年會，台北，台灣。
    H. M. M. Ahmed、陳冠?、林維哲、歐柏榮、鄭登貴(2012. 12)「餵飼川芎對女豬對發情同期化」中國畜牧年會，台北，台灣。
  • 唐翊家、歐柏榮、陳韋岑、李彥勳、葉貞吟*。(2013. 3) 「豬血管內皮細胞中與砷排除相關多重抗藥性輸送子之基因表現」(Gene expression of multidrug resistance-associated transporters related to arsenic exclusion in porcine aortic endothelial cells)，The 28th Joint Annual Conference of Biomedical Science (第二十八屆生物醫學聯合學術年會), Taipei, Taiwan R.O.C.
  • Ahmed, M., Cheng, T. K., Yeh, J. Y. and Ou, B. R.* (2013. 3) 「中草藥的助孕活性與抗助孕活性」(Progestative and anti-progestative activities in chinese medicinal plants) )，The 28th Joint Annual Conference of Biomedical Science (第二十八屆生物醫學聯合學術年會), Taipei, Taiwan R.O.C.
  • 黃鈴雅、林維哲、李孟修、鄭登貴、施宗雄、歐柏榮。 (2014.12)「飼料中添加不同濃度發酵茶渣對雞蛋品質及蛋雞膽固醇含量之影響」中國畜牧年會，台北，台灣。

    周峻賢、陳憬輝、陳佩寧、葉貞吟、鄭登貴、歐柏榮。 (2014. 12) 「選殖地衣芽孢桿菌β-1,3-1,4-葡萄聚醣?基因及其在大腸桿菌之表現」中國畜牧年會，台北，台灣。

  • 陳冠?、 尤亮恩、 葉貞吟、 鄭登貴、 歐柏榮。 (2014. 12)「植物乳桿菌胞外分泌人類防禦素5之載體構築」中國畜牧年會，台北，台灣。
  • Nileema R. Divate, Gen-Hung Chen, Pei-Ming Wang, Bor-Rung Ou, and Yun-Chin Chung. 2016. Engineering Saccharomyces cerevisiae for improvement in ethanol tolerance by accumulation of trehalose. Bioengineered DOI: 10.1080/21655979.2016.1207019
  • Charles, L., Yeh, J. Y., Huang T.C., Ou, B. R. 2010. The influence of structural properties and biological functions of sweet cassava and seaweed polysaccharides.Food Hydrocolloids : Characteristics, Properties and Structures
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